Hydrochloric Acid → N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-(2-amino-6-chloro-4-pyrimidinyl)amine

HRID 16434

반응식

HRID 16434 반응식
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[C:12]3[C:13]([NH2:16])=[N:14][O:15][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[C:4]([F:19])[CH:3]=1.[NH2:20][C:21]1[N:26]=[C:25](Cl)[CH:24]=[C:23]([Cl:28])[N:22]=1.Cl>O>[NH2:16][C:13]1[C:12]2[C:7]([O:6][C:5]3[CH:17]=[CH:18][C:2]([NH:1][C:25]4[CH:24]=[C:23]([Cl:28])[N:22]=[C:21]([NH2:20])[N:26]=4)=[CH:3][C:4]=3[F:19])=[CH:8][CH:9]=[CH:10][C:11]=2[O:15][N:14]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 655222-Amino-4,6-dichloropyrimidineHCID 179792974-(4-Amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine

생성물 1

HCID 17979320N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-(2-amino-6-chloro-4-pyrimidinyl)amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

100 mg (0.39 mmol) of 4-(4-amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine (from example VII) and 63.3 mg (0.39 mmol) of 2-amino-4,6-dichloropyrimidine are suspended in 3 ml of water, and 0.04 ml of concentrated hydrochloric acid is added. The reaction mixture is heated at reflux overnight, resulting in the formation of a colorless precipitate. This is filtered off, washed repeatedly with water and dried under high vacuum.

후처리

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux overnight
  3. customresulting in the formation of a colorless precipitate
  4. filtrationThis is filtered off
  5. washwashed repeatedly with water
  6. customdried under high vacuum

출처 및 근거

ORD 기록
ord-6909c9ea790740398f5e862b25298d5e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

연결된 노트

불러오는 중…