Methyl 3-isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoate → 3-Isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoic acid

HRID 1644584

반응식

HRID 1644584 반응식
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:14]=1)[C:8]([O:10]C)=[O:9])([CH3:3])[CH3:2]>C1COCC1.CO.[OH-].[Na+]>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:14]=1)[C:8]([OH:10])=[O:9])([CH3:3])[CH3:2]

참가 물질

5

반응물 1

HCID 66775698Methyl 3-isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoate

생성물 1

HCID 592430633-Isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoic acid수율 60%

시약·촉매·용매 3

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 14798Sodium Hydroxide용매

실험 절차

Methyl 3-isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoate (2.70 g) was dissolved in a mixed solvent of THF (30 ml) and methanol (30 ml), and 1N aqueous sodium hydroxide solution (25 ml) was added to the mixed solution. The mixture was stirred overnight at room temperature and concentrated under reduced pressure to dryness. 1N Aqueous hydrochloric acid solution (25 ml) was added thereto, and the precipitated crystals were collected by filtration and washed with water to give 3-isopropoxy-5-(3-pyridin-3-ylpropoxy)benzoic acid (1.55 g, 60%) as colorless crystals.

후처리

  1. additionwas added to the mixed solution
  2. concentrationconcentrated under reduced pressure to dryness
  3. addition1N Aqueous hydrochloric acid solution (25 ml) was added
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed with water

출처 및 근거

ORD 기록
ord-41d24c51cc214bbd9ccdddf2cfe23458
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124617B2

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