Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2-Dimethylsuccinic anhydride → 4-(4-{4-[(1-Ethyl-4-methyl-4H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2-Dimethylsuccinic anhydride | HCID 87067 | — |
| 반응물 | 4-(4-{5-[(4-Chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acid | HCID 46207828 | — |
| 반응물 | 4-(4-{4-[(1-ethyl-4-methyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid | HCID 59365134 | — |
| 반응물 | 1-ethyl-4-methyl-1H-indole-2-carboxylic acid (4-piperidin-4-yl-phenyl)-amide | HCID 66772392 | — |
| 생성물 | 4-(4-{4-[(1-Ethyl-4-methyl-4H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid | HCID 66772377 | — |
반응 단계
With a method similar to that used for the preparation of 4-(4-{5-[(4-chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acid, 4-(4-{4-[(1-ethyl-4-methyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid was prepared from 1-ethyl-4-methyl-1H-indole-2-carboxylic acid (4-piperidin-4-yl-phenyl)-amide and 2,2-dimethylsuccinic anhydride. LCMS for C29H35N3O4 calcd. (m/e) 489, observed 490 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08124766B2 |
| 출처 데이터셋 | uspto-grants-2012_02 |
| ORD ID | ord-b85c8fdf67f94dcab7d1dd502c3a8771 |
| 출처 메모 | uspto-grants-2012_02 |