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Perchloric Acid → 5,6-Dimethoxy-2-(pyridin-4-ylmethyl)indan-1-one

HRID 1645380
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HRID 1645380 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[C:7](=[CH:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[CH2:6]2.Cl(O)(=O)(=O)=O>CO.ClCCl.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH:7]([CH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[CH2:6]2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 24247Perchloric AcidHCID 533951325,6-Dimethoxy-2-(4-pyridyl)methylene-1-indanone

생성물 1

HCID 100852305,6-Dimethoxy-2-(pyridin-4-ylmethyl)indan-1-one

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

4-[(5,6-Dimethoxy-1-indanon-2-ylidene)methyl]pyridine (50 g) in methanol and dichloromethane (1:1) was hydrogenated in presence of palladium on carbon (5 g) and a catalytic quantity of perchloric acid at 0.5 kg pressure and room temperature. The solvents were evaporated under vacuum and the residue was taken in ethyl acetate (500 ml), washed with water (50 ml), brine (50 ml), dried over anhydrous sodium sulphate and evaporated in vacuum to yield the product. Yield: 49 g.

후처리

  1. customat 0.5 kg pressure and room temperature
  2. customThe solvents were evaporated under vacuum
  3. washwashed with water (50 ml), brine (50 ml)
  4. dry with materialdried over anhydrous sodium sulphate
  5. customevaporated in vacuum
  6. customto yield the product

출처 및 근거

ORD 기록
ord-404de8b9b4704b9091687f65c4017a9a
출처 데이터셋
uspto-grants-2012_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08124783B2

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