Water → Ethyl 3-difluoromethyl-1-methyl-4-pyrazole carboxylate

HRID 1645383노트

반응식

HRID 1645383 반응식
[CH3:1][NH:2][NH2:3].O.[CH2:5]([O:7][C:8](=[O:19])/[C:9](=[CH:15]\OCC)/[C:10](=O)[CH:11]([F:13])[F:12])[CH3:6]>C1(C)C(C)=CC=CC=1>[F:12][CH:11]([F:13])[C:10]1[C:9]([C:8]([O:7][CH2:5][CH3:6])=[O:19])=[CH:15][N:2]([CH3:1])[N:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6061Methylhydrazine2회HCID 44185486HCID 44185486, 화합물

생성물 1

HCID 11644126Ethyl 3-difluoromethyl-1-methyl-4-pyrazole carboxylate

시약·촉매·용매 1

HCID 7237O-Xylene용매2회

실험 절차

A 0.25 mol solution of methylhydrazine 40% diluted in 50.0 g xylene and 4.7 g water was prepared. A solution of 0.25 mol of 2-[1-Ethoxy-meth-(Z)-ylidene]-4,4-difluoro-3-oxo-butyric acid ethyl ester in 100.0 g xylene was added to the methylhydrazine over 30-60 minutes at a temperature of 20-25° C. The reaction mixture was stirred for 15 min. The phases of the reaction mass were separated.

후처리

  1. customThe phases of the reaction mass were separated

출처 및 근거

ORD 기록
ord-92555f4c20a0434a9d6ca300b0fc6109
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124787B2

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