Sodium Iodide → HCID 131729476, 화합물

HRID 1645411노트

반응식

HRID 1645411 반응식
[CH2:1]1[S:9](=[O:11])(=[O:10])[O:8][CH2:7][CH2:6][O:5][S:2]1(=[O:4])=[O:3].[H-].[Na+].Cl[CH2:15][C:16]1[C:25]2[C:20](=CC=C[CH:24]=2)[CH:19]=[CH:18][CH:17]=1.[Na+].[I-].[CH2:28]([CH2:31]OC)OC>>[CH:24]1[C:25]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:6][C:7]=1[O:8][S:9]([CH:1]([S:2]([OH:5])(=[O:4])=[O:3])[CH3:28])(=[O:11])=[O:10].[CH2:28]=[CH2:31]

참가 물질

6

반응물 5

HCID 5238Sodium IodideHCID 68451-ChloromethylnaphthaleneHCID 80711,2-DimethoxyethaneHCID 24758Sodium hydrideHCID 57513Cyclodisone

생성물 1

HCID 131729476HCID 131729476, 화합물수율 86%

실험 절차

To a solution of 3.5 g of ethylene methanedisulfonate in 60 mL of glyme and 0.9 g of NaH was added 3.4 g of 1-chloromethylnaphthalene followed by 2.6 g of NaI. The solution was stirred overnight and the glyme removed by the rotary evaporator at 20 mm pressure. The residue was taken up in an acid solution and CH2Cl2. The CH2Cl2 was rinsed with a NaHSO3 solution, dried, concentrated, and cyclohexane was added to give 3.9 g (86%) of ethylene 2-naphthyl-1,1-ethanedisulfonate, m.p. 179-183° C. (94-2).

후처리

  1. customthe glyme removed by the rotary evaporator at 20 mm pressure
  2. washThe CH2Cl2 was rinsed with a NaHSO3 solution
  3. customdried
  4. concentrationconcentrated
  5. additioncyclohexane was added

출처 및 근거

ORD 기록
ord-345c017f3a8b405a8e8100fe5c8afcba
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124793B2

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