1-Chloroheptane → Heptylbenzene

HRID 1645707

반응식

HRID 1645707 반응식
[CH2:1](Cl)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[C:9]1([Mg]Cl)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[Cl-].[NH4+]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1(C)C=CC([B-](C2C=CC(C)=CC=2)(C2C=CC(C)=CC=2)C2C=CC(C)=CC=2)=CC=1.C1([PH+](C2CCCCC2)C2CCCCC2)CCCCC1.O1CCCC1.CN1CCCC1=O>[C:9]1([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

8

반응물 3

HCID 123711-ChloroheptaneHCID 25517Ammonium ChlorideHCID 178478979HCID 178478979, 화합물

생성물 1

HCID 14115Heptylbenzene

시약·촉매·용매 4

HCID 167845palladium(II) acetate촉매HCID 23136666Tricyclohexylphosphonium tetra-para-tolylborate촉매HCID 8028Tetrahydrofuran용매2회HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

A 30-ml four-necked flask was equipped with a stirrer, a thermometer, a dropping funnel and a reflux condenser. 0.027 g (0.12 mmol) of palladium (II) acetate and 7 ml of N-methylpyrrolidinone were weighed in the flask, followed by stirring. Further, 0.079 g (0.12 mmol) of tricyclohexylphosphonium tetra-para-tolylborate obtained in Example B-16 was weighed in air and added into the flask. The flask was purged with argon, followed by stirring at 25° C. for 30 minutes. 0.404 g (3 mmol) of n-heptyl chloride was added, followed by stirring at 25° C. for 30 minutes. 2 ml (4.4 mmol) of 2.2M tetrahydrofuran solution of phenylmagnesium chloride was added dropwise at 25° C. over a period of 10 minutes, followed by stirring at 25° C. for 19 hours. After the completion of the reaction, 6 ml of tetrahydrofuran and 10 ml of saturated aqueous ammonium chloride solution were added, followed by separation. The organic phase was purified by column chromatography to afford 0.434 g of 1-phenylheptane (yield: 82 mol % based on n-heptyl chloride). The identification of the product was made by mass spectroscopy.

후처리

  1. customA 30-ml four-necked flask was equipped with a stirrer
  2. additionadded into the flask
  3. customThe flask was purged with argon
  4. stirringby stirring at 25° C. for 30 minutes
  5. stirringby stirring at 25° C. for 30 minutes
  6. stirringby stirring at 25° C. for 19 hours
  7. additionwere added
  8. customfollowed by separation
  9. customThe organic phase was purified by column chromatography

출처 및 근거

ORD 기록
ord-c9c34d3ced3241cb8175dd326573df44
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124809B2

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