HCID 19100959, 화합물 → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1646002노트

반응식

HRID 1646002 반응식
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

참가 물질

3

반응물 1

HCID 19100959HCID 19100959, 화합물

생성물 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo [3.3.0]octane-7-carboxylate are heated under reflux overnight with 30 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate, extracted five times with 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

후처리

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times with 50 ml of chloroform each time
  3. dry with materialdried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-cef2e45a06914095b2a51f8c76928a80
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05177210

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