Potassium Carbonate → Decahydropyrrolo[3,4-b]pyrrolizine

HRID 1646006노트

반응식

HRID 1646006 반응식
[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][N:4](C(OCC)=O)[CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>Cl>[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][NH:4][CH2:5]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 53870311Ethyl 1,4-diazatricyclo[6.3.0.02,6]undecane-4-carboxylate

생성물 1

HCID 16227934Decahydropyrrolo[3,4-b]pyrrolizine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

9 g (40 mmol) of ethyl 1,4-diazatricyclo[6.3.0.02,6 ]undecane-4-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

후처리

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-702abfdf4e02406098aa7935e3ca8612
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05177210

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