HCID 19100973, 화합물 → HCID 19100943, 화합물

HRID 1646028노트

반응식

HRID 1646028 반응식
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

참가 물질

3

반응물 1

HCID 19100973HCID 19100973, 화합물

생성물 1

HCID 19100943HCID 19100943, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight in 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 20 ml of water, the mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

후처리

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-675a6290edcf469b92f6568d3aba1b4c
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05177210

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