Sodium Hydroxide → 2-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-ethoxy-3-methylbutanoic acid

HRID 1646141노트

반응식

HRID 1646141 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH:12]([C:18]([O:21][CH2:22][CH3:23])([CH3:20])[CH3:19])[C:13]([O:15]CC)=[O:14])[N:4]=1.[OH-].[Na+]>C(O)C>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH:12]([C:18]([O:21][CH2:22][CH3:23])([CH3:19])[CH3:20])[C:13]([OH:15])=[O:14])[N:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19801421HCID 19801421, 화합물

생성물 1

HCID 157671522-((4,6-Dimethoxypyrimidin-2-yl)oxy)-3-ethoxy-3-methylbutanoic acid수율 85%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

That is, to Compound 50 (32.8 g, 0.1 mol) prepared in the above (1) dissolved in ethanol (100 ml) was added 5N sodium hydroxide (40 ml), and the mixture was stirred for one hour. Subsequently, ethanol was removed under reduced pressure, 5N hydrochloric acid (50 ml) was added to the residue obtained, and the residue was extracted with chloroform. The chloroform layer was washed with water and dried, and then chloroform was removed under reduced pressure to obtain 25.5 g (yield: 85.0%) of the title compound as white crystals.

후처리

  1. customSubsequently, ethanol was removed under reduced pressure, 5N hydrochloric acid (50 ml)
  2. additionwas added to the residue
  3. customobtained
  4. extractionthe residue was extracted with chloroform
  5. washThe chloroform layer was washed with water
  6. customdried
  7. customchloroform was removed under reduced pressure

출처 및 근거

ORD 기록
ord-31250134ec8c416bbed180a23992cb78
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05178663

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