4-Hydroxy-N-methylcarbostyril → 1-methyl-3-dimethylaminomethylene-(1H)-quinolin-2,4-dione
반응식
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][C:3]1=[O:13]>COC(OC)N(C)C.C(Cl)Cl>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[C:4](=[CH:1][N:2]([CH3:11])[CH3:3])[C:3]1=[O:13]참가 물질
4
실험 절차
A suspension of 1-methyl-4-hydroxy-2(1H)-quinolinone (1.0 gm) in dimethyl formamide dimethyl acetal (5 ml) and methylene chloride (2.0 ml) was refluxed for 1 hour. The resulting dark orange solution was evaporated under reduced pressure to afford 1-methyl-3-dimethylaminomethylene-(1H)-quinolin-2,4-dione. MS: m/e 230 (M+). ##STR37##
후처리
- temperaturewas refluxed for 1 hour
- customThe resulting dark orange solution was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-e8d5418d5c764c8793899602fc149752
- 출처 데이터셋
- uspto-grants-1993_01
- 특허 번호
- US05179093
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