Methyl 4-(bromomethyl)-3-methoxybenzoate → HCID 178497911, 화합물

HRID 1646359노트

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HRID 1646359 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([OH:13])=[N:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[Na].Br[CH2:16][C:17]1[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][C:18]=1[O:27][CH3:28]>CO.CN(C)C=O.C(OCC)(=O)C>[OH:13][C:8]1[C:7]2[C:11](=[CH:12][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[N:10]([CH2:16][C:17]2[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][C:18]=2[O:27][CH3:28])[N:9]=1

참가 물질

7

반응물 3

HCID 2759828Methyl 4-(bromomethyl)-3-methoxybenzoateHCID 5360545SodiumHCID 178526464HCID 178526464, 화합물

생성물 1

HCID 178497911HCID 178497911, 화합물수율 38.5%

시약·촉매·용매 3

HCID 887Methanol용매2회HCID 6228Dimethylformamide용매2회HCID 8857Ethyl Acetate용매

반응 조건

온도
50 °C

실험 절차

6-Nitroindazolol (0.206 g.) was added to a solution of sodium (0.026 g.) in methanol (1.5 ml.), and the mixture heated at 50° C. for 10 minutes. A solution of methyl 4-bromomethyl-3-methoxybenzoate (B) (0.327 g.) in methanol (3.75 ml.) and N,N-dimethylformamide (DMF) (1.25 ml.) was added, and the mixture was refluxed for 18 hours. The cooled mixture was diluted with ethyl acetate and DMF, and washed with water and brine, then dried (MgSO4) and evaporated. The residue was triturated with 1:1 v/v ethyl acetate:ether to give methyl 4-[3-hydroxy-6-nitroindazol-1-ylmethyl]-3-methoxybenzoate (T) (0.158 g., 38%) as a yellow solid, m.p. 231°-235° C.

후처리

  1. temperaturethe mixture was refluxed for 18 hours
  2. washwashed with water and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customThe residue was triturated with 1:1 v/v ethyl acetate

출처 및 근거

ORD 기록
ord-ecbf6908276343cabee39ae9c61a0205
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05179112

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