Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → N-[4-(1-t-butoxyformamido)butyryl]-beta-alanine benzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | 4-(((Tert-butoxy)carbonyl)amino)butanoic acid | HCID 294894 | — |
| 반응물 | Chloro-dimethoxy-triazine | HCID 12493616 | — |
| 반응물 | 4-Methylbenzene-1-sulfonic acid--benzyl beta-alaninate (1/1) | HCID 13502100 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-[4-(1-t-butoxyformamido)butyryl]-beta-alanine benzyl ester | HCID 19926286 | — |
반응 단계
4-(t-Butoxycarbonylamino)butyric acid in THF was activated with chlorodimethoxytriazine and N-methylmorpholine and reacted with β-alanine benzyl ester p-toluenesulphonate in the presence of N-methylmorpholine to give N-[4-(1-t-butoxyformamido)butyryl]-β-alanine benzyl ester, m.p. 54°-55° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05430024 |
| 출처 데이터셋 | uspto-grants-1995_07 |
| ORD ID | ord-905cec476ae5498284b5479022b6f3b5 |
| 출처 메모 | uspto-grants-1995_07 |