Triethylamine → Dimethylaminopropyl thiohydantoin valine

HRID 1647383

반응식

HRID 1647383 반응식
C([O:3][C:4](=[O:10])[C@H:5]([CH:7]([CH3:9])[CH3:8])[NH2:6])C.[CH3:11][N:12]([CH2:14][CH2:15][CH2:16][N:17]=[C:18]=[S:19])[CH3:13].[CH2:20]([N:22](CC)CC)[CH3:21]>CO>[NH2:6][C@H:5]([C:4]([OH:10])=[O:3])[CH:7]([CH3:9])[CH3:8].[CH3:11][N:12]([CH2:14][CH2:15][CH2:16][N:17]1[CH2:21][C:20](=[O:3])[NH:22][C:18]1=[S:19])[CH3:13]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 87182l-Valine, ethyl esterHCID 1413513-((Dimethylamino)phenyl isothiocyanate

생성물 1

HCID 86748773Dimethylaminopropyl thiohydantoin valine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Valine ethyl ester (0.01 mol) in 30 ml of anhydrous methanol was reacted with dimethylaminopropyl isothiocyanate (0.01 mol) for 3 hours at 50° C. The solution was made basic by the addition of two equivalents of triethylamine. Solvent was removed by rotary evaporation. Water was added to the solid residue and the residue was filtered and washed with water. The residue was dissolved in methanol and analyzed by FAB/MS. The expected product, dimethylaminopropyl thiohydantoin valine (MH+=244), was obtained.

후처리

  1. customSolvent was removed by rotary evaporation
  2. additionWater was added to the solid residue
  3. filtrationthe residue was filtered
  4. washwashed with water
  5. dissolutionThe residue was dissolved in methanol

출처 및 근거

ORD 기록
ord-433c315089c44813a8711837dd95fa0e
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05432093

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