Trifluoroacetic acid → 4,6-Bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile

HRID 1647417

반응식

HRID 1647417 반응식
[CH3:1][C:2]([C:5]1[C:10]([O:11]COCCOC)=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[N:8]=[C:7]([C:22]#[N:23])[N:6]=1)([CH3:4])[CH3:3].FC(F)(F)C(O)=O>>[CH3:4][C:2]([C:5]1[C:10]([OH:11])=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[N:8]=[C:7]([C:22]#[N:23])[N:6]=1)([CH3:1])[CH3:3]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 199229864,6-Bis(1,1-dimethylethyl)-5-[(2-methoxyethoxy)-methoxy]-2-pyrimidinecarbonitrile

생성물 1

HCID 152948974,6-Bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile수율 68.2%

실험 절차

According to the procedure of Example 18, 4,6-bis(1,1-dimethylethyl) -5-[(2-methoxyethoxy)methoxy]-2-pyrimidine carbonitrile (9.1 g, 28.3 mmol) is treated with trifluoroacetic acid to give 4,6-bis(1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile (4.5 g, 68%); mp 203°-205° C.

출처 및 근거

ORD 기록
ord-c489861f71f146a69ac58151c26e9de4
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05432181

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