Phosphorus oxychloride → HCID 10377394, 화합물

반응식

[C:1]([C:5]1[C:14](=O)[C:13]2[C:8](=[C:9]([O:16][CH3:17])[CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)(=[O:4])[CH2:2][CH3:3].P(Cl)(Cl)([Cl:20])=O>>[C:1]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[Cl:20])=[CH:12][CH:11]=[CH:10][C:9]=2[O:16][CH3:17])(=[O:4])[CH2:2][CH3:3]

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 10036866HCID 10036866, 화합물

생성물 1

HCID 10377394HCID 10377394, 화합물

실험 절차

3-Propanoyl-8-methoxy-4(1H)-quinolone (35.4 g, 0.15 mol) was dissolved in phosphoryl chloride (400 ml) and heated at reflux for 1 hour, then the excess phosphoryl chloride evaporated. The residue was mixed with ice, then diluted with water and extracted into dichloromethane. Drying and evaporation gave 3-propanoyl-4-chloro-8-methoxyquinoline (39.7 g) as a dark oil which was used without further purification.

후처리

temperatureheated
temperatureat reflux for 1 hour
customthe excess phosphoryl chloride evaporated
additionThe residue was mixed with ice
additiondiluted with water
extractionextracted into dichloromethane
customDrying
customevaporation

출처 및 근거

ORD 기록: ord-3ad91f5d8fea473e9f4e3f9b0ea3da2c
출처 데이터셋: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05432182

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