Glycine → O-methoxymethyl-beta-hydroxytyrosine

HRID 1648174노트

반응식

HRID 1648174 반응식
[OH-].[K+].[NH2:3][CH2:4][C:5]([OH:7])=[O:6].[CH3:8][O:9][CH2:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][CH:13]=1>C(O)C>[CH3:8][O:9][CH2:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]([OH:17])[C@@H:4]([C:5]([OH:7])=[O:6])[NH2:3])=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 750GlycineHCID 14797Potassium HydroxideHCID 2500744-(Methoxymethoxy)benzaldehyde

생성물 1

HCID 54167947O-methoxymethyl-beta-hydroxytyrosine수율 19.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of potassium hydroxide (26.8 g) in ethanol (500 ml) was added glycine (14.6 g) and 4-methoxymethoxybenzaldehyde (48.5 g) at room temperature. After stirring for 19 hours, the solvent was removed in vacuo. The residue was dissolved in water and acidified with hydrochloric acid. The solution was washed with ethyl acetate and adjusted to pH 6.0 with sodium bicarbonate. White solid was precipitated and collected to give O-methoxymethyl-β-hydroxytyrosine (9.2 g).

후처리

  1. customthe solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in water
  3. washThe solution was washed with ethyl acetate
  4. customWhite solid was precipitated
  5. customcollected

출처 및 근거

ORD 기록
ord-cde470487215418c8df1b92e55c6603a
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436140

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