Water → 1H-Pyrrole, 1-benzoyl-2,5-dihydro-

HRID 1648475

반응식

HRID 1648475 반응식
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Br[CH2:13]/[CH:14]=[CH:15]\[CH2:16]Br.O>C1(C)C=CC=CC=1.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]([N:9]1[CH2:16][CH:15]=[CH:14][CH2:13]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 2331BenzamideHCID 14797Potassium HydroxideHCID 5354994(Z)-1,4-dibromobut-2-ene

생성물 1

HCID 112522831H-Pyrrole, 1-benzoyl-2,5-dihydro-

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 1140Toluene용매

반응 조건

온도
40 °C

실험 절차

121 g (1 mol) of benzamide in 3 l of toluene are introduced initially, 200 g of powdered potassium hydroxide are introduced with stirring, 32 g (0.1 mol) of tetrabutylammonium bromide are added and the mixture is heated to 40° C. 243 g (1 mol) of 88% cis-1,4-dibromo-2-butene are then added dropwise in such a way that the internal temperature does not exceed 60° C. The mixture is stirred for another 5 hours at 50° C., then poured into water, and the organic phase is separated off, washed with water, dried and concentrated. The residue is distilled under reduced pressure.

후처리

  1. customdoes not exceed 60° C
  2. stirringThe mixture is stirred for another 5 hours at 50° C.
  3. customthe organic phase is separated off
  4. washwashed with water
  5. customdried
  6. concentrationconcentrated
  7. distillationThe residue is distilled under reduced pressure

출처 및 근거

ORD 기록
ord-6ef41715b4a041a9bc6dc8d77e639fe4
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436334

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