Acetohydroxamic Acid → Caracemide
반응식
[C:1]([NH:4][OH:5])(=[O:3])[CH3:2].[CH3:6][N:7]=[C:8]=[O:9]>C(N(CC)CC)C.C(Cl)Cl>[CH3:6][NH:7][C:8]([N:4]([O:5][C:8]([NH:7][CH3:6])=[O:9])[C:1](=[O:3])[CH3:2])=[O:9]참가 물질
5
실험 절차
A mixture of acetohydroxamic acid (7.5 grams), methyl isocyanate (12.0 grams), 80 milliliters (ml) of methylene chloride, and about three drops of triethylamine were stirred together for about one hour in order to obtain solution. The solution was allowed to stand at room temperature overnight after which the solvent was removed under vacuum, leaving a residue. The residue was recrystallized from methylene chloride leaving the desired N-((methylamino)carbonyl)-N-(((methylamino)carbonyl)oxy)acetamide as white crystals having a melting point (m.p.) of 121°-123.5° C.
후처리
- customto obtain solution
- waitto stand at room temperature overnight
- customafter which the solvent was removed under vacuum
- customleaving a residue
- customThe residue was recrystallized from methylene chloride leaving the desired N-((methylamino)carbonyl)-N-(((methylamino)carbonyl)oxy)acetamide as white crystals
- customa melting point (m.p.) of 121°-123.5° C.
출처 및 근거
- ORD 기록
- ord-bda5ec0b37944ff997791b0f58c60577
- 출처 데이터셋
- uspto-grants-1983_11
- 특허 번호
- US04413009
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