Methyl Isocyanate → HCID 13228806, 화합물

HRID 1648764노트

반응식

HRID 1648764 반응식
[C:1]([NH:5][OH:6])(=[O:4])[CH2:2][CH3:3].[CH3:7][N:8]=[C:9]=[O:10]>C(N(CC)CC)C.C(Cl)Cl>[CH3:7][NH:8][C:9]([N:5]([O:6][C:9]([NH:8][CH3:7])=[O:10])[C:1](=[O:4])[CH2:2][CH3:3])=[O:10]

참가 물질

5

반응물 2

HCID 12228Methyl IsocyanateHCID 75743N-Hydroxypropanamide

생성물 1

HCID 13228806HCID 13228806, 화합물

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 6344Dichloromethane용매

실험 절차

Propiohydroxamic acid (4.5 grams), methyl isocyanate (6.0 grams), and a few drops of triethylamine were stirred for about one hour in about 50 ml of methylene chloride. The resulting solution was allowed to stand at room temperature for about 48 hours, after which the solvent was removed by evaporation leaving a residue. The residue was recrystallized from a mixture of methylene chloride and hexane leaving the desired, N-((methylamino)carbonyl)-N-(((methylamino)carbonyl)-oxy)propionamide as white crystals, m.p. 90.5°-92.5° C.

후처리

  1. customafter which the solvent was removed by evaporation
  2. customleaving a residue
  3. customThe residue was recrystallized from a mixture of methylene chloride and hexane leaving the

출처 및 근거

ORD 기록
ord-1849293a7a1545c9abd3053cf99f1cbd
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04413009

반응 노트

불러오는 중…