Propyl isocyanate → HCID 13228803, 화합물

HRID 1648768노트

반응식

HRID 1648768 반응식
[OH:1][NH:2][C:3]([CH:5]1[CH2:7][CH2:6]1)=[O:4].[CH2:8]([N:11]=[C:12]=[O:13])[CH2:9][CH3:10]>C(N(CC)CC)C.C(Cl)Cl>[CH2:8]([NH:11][C:12]([N:2]([O:1][C:12]([NH:11][CH2:8][CH2:9][CH3:10])=[O:13])[C:3]([CH:5]1[CH2:7][CH2:6]1)=[O:4])=[O:13])[CH2:9][CH3:10]

참가 물질

5

반응물 2

HCID 61033Propyl isocyanateHCID 9989224N-hydroxycyclopropanecarboxamide

생성물 1

HCID 13228803HCID 13228803, 화합물

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 6344Dichloromethane용매

실험 절차

N-hydroxycyclopropanecarboxamide (5.0 grams), n-propyl isocyanate (9.3 grams) and 5 drops of triethylamine were stirred at room temperature in about 100 ml of methylene chloride for about 12 hours. The reaction mixture was then concentrated leaving an oily residue which crystallized upon scratching. This solid was then recrystallized from a mixture of cyclohexane and isopropanol and dried. Upon drying, the desired N-((propylamino)carbonyl)-N-(((propylamino)carbonyl)-oxy)cyclopropanecarboxamide was obtained as a white solid, m.p. 76°-78° C.

후처리

  1. concentrationThe reaction mixture was then concentrated
  2. customleaving an oily residue which
  3. customcrystallized
  4. customThis solid was then recrystallized from a mixture of cyclohexane and isopropanol
  5. customdried
  6. customUpon drying

출처 및 근거

ORD 기록
ord-852ccd5ecccd420cb879adc1a6e7f2c2
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04413009

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