2-Methoxyaniline → Acetamide, N-(2-methoxyphenyl)-

HRID 1648957

반응식

HRID 1648957 반응식
[CH3:1][O:2][C:3]1[C:4]([NH2:9])=[CH:5][CH:6]=[CH:7][CH:8]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[CH3:11][C:10]([NH:9][C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:12]

참가 물질

3

반응물 2

HCID 70002-MethoxyanilineHCID 7918Acetic Anhydride

생성물 1

HCID 7135Acetamide, N-(2-methoxyphenyl)-

반응 조건

온도
45 °C

실험 절차

To 100 ml of acetic anhydride was added dropwise with stirring 100 g (0.813 mole) of o-anisidine, the temperature rising to about 60° C. during addition. The reaction mixture was heated on a steam bath for 15 minutes, allowed to cool to 45° C. and was poured onto 500 g of crushed ice. The white solid that precipitated was collected, washed free of acid with water and air dried to give 100 g, m.p. 84°-86° C., of product.

후처리

  1. additionthe temperature rising to about 60° C. during addition
  2. temperatureThe reaction mixture was heated on a steam bath for 15 minutes
  3. customThe white solid that precipitated
  4. customwas collected
  5. washwashed free of acid with water and air
  6. customdried
  7. customto give 100 g, m.p. 84°-86° C.

출처 및 근거

ORD 기록
ord-dd72855b9a824be39a73e3a9415ab444
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04414320

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