Diethyl Ether → N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

HRID 1649044노트

반응식

HRID 1649044 반응식
[NH:1]=[C:2]1[N:6]([CH3:7])[CH2:5][CH2:4][S:3]1.[C:8]1([N:14]=[C:15]=[S:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.CCOCC>C1C=CC=CC=1>[CH3:7][N:6]1[CH2:5][CH2:4][S:3][C:2]1=[N:1][C:15]([NH:14][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[S:16]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 7673Phenyl IsothiocyanateHCID 773183-Methyl-1,3-thiazolidin-2-imine

생성물 1

HCID 54546998N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea수율 75%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 0.043 mole of 2-imino-3-methylthiazolidine and an equimolar amount of phenylisothiocyanate in 70 ml of dry benzene is refluxed under nitrogen for 2.5 hours. Some ether is added to the cooled reaction mixture and solids are filtered off, 9.8 g (90%). Recrystallization from acetonitrile-ether (1:1) gives 8.0 g (75%) of pure N-(3-methyl-2-thiazolidinylidene)-N'-phenylthiourea; m.p. 168.5°-170.5° C.

후처리

  1. filtrationare filtered off
  2. customRecrystallization from acetonitrile-ether (1:1)

출처 및 근거

ORD 기록
ord-48d0ad4196374bd6a78daf7039b1f5b7
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04414211

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