Methyl iodide → HCID 70508978, 화합물

HRID 1649045노트

반응식

HRID 1649045 반응식
[CH3:1][N:2]1[CH2:6][CH2:5][S:4][C:3]1=[N:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[S:9].[I:17][CH3:18]>CC(C)=O>[IH:17].[CH3:1][N:2]1[CH2:6][CH2:5][S:4][C:3]1=[N:7][C:8]([S:9][CH3:18])=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 54546998N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea

생성물 1

HCID 70508978HCID 70508978, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A suspension of 17.0 g (0.067 mole) of N-(3-methyl-2-thiazolidinylidene)-N'-phenylthiourea and 11.1 g (0.078 mole) of iodomethane in 350 ml of acetone is refluxed for one hour. The solution is cooled at room temperature overnight (about 16 hours) and solids are filtered off, 25.1 g (95.2%), m.p. 159.5°-161.5° C. Recrystallization from methanol-ether (1:1) gives pure methyl N-(3-methyl-2-thiazolidinylidene)-N'-phenylcarbamimidothioate hydroiodide; m.p. 163.5°-165° C.

후처리

  1. temperatureis refluxed for one hour
  2. filtrationare filtered off
  3. customRecrystallization from methanol-ether (1:1)

출처 및 근거

ORD 기록
ord-0ee6710d7b214a5480747b4f63ea6684
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04414211

반응 노트

불러오는 중…