Hydroxyamine hydrochloride → 3-Phenyl-1H-5-indazolecarbonitrile
반응식
[CH:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O.Cl.[NH2:19]O.C([O-])=O.[Na+]>C(O)=O>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)#[N:19]참가 물질
5
실험 절차
A mixture of 22 g of 5-formyl-3-phenylindazole, 8 g of hydroxylamine hydrochloride and 12.5 g of sodium formate was added to 150 ml of formic acid, and after refluxing for 2 hours, the mixture was extracted with chloroform. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated to give 16.5 g of 5-cyano-3-phenylindazole (m.p. 150°-151° C.).
후처리
- temperatureafter refluxing for 2 hours
- extractionthe mixture was extracted with chloroform
- washThe extract was washed with water
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-ddde8d3f43fc41eea8b0eccd7d00c7dc
- 출처 데이터셋
- uspto-grants-1983_11
- 특허 번호
- US04415569
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