Benzene → Tricine

HRID 1649534

반응식

HRID 1649534 반응식
[CH3:1][N:2]([C:4]1[C:9]2[CH2:10][C@@H:11]3[C:21]([C:22](=[O:23])[C:8]=2[C:7]([OH:33])=[CH:6][CH:5]=1)=[C:20]([OH:24])[C@@:19]1([OH:25])[C@H:13]([C@H:14]([N:30]([CH3:32])[CH3:31])[C:15]([OH:29])=[C:16]([C:26]([NH2:28])=[O:27])[C:17]1=[O:18])[CH2:12]3)[CH3:3].C1C=CC=CC=1.[CH3:40][OH:41].C([OH:44])C.C[C:46]([N:48](C)C)=O>CN(C)C=O.C(OCC)(=O)C>[CH3:3][N:2]([C:4]1[C:9]2[CH2:10][C@@H:11]3[C:21]([C:22](=[O:23])[C:8]=2[C:7]([OH:33])=[CH:6][CH:5]=1)=[C:20]([OH:24])[C@@:19]1([OH:25])[C@H:13]([C@H:14]([N:30]([CH3:32])[CH3:31])[C:15]([OH:29])=[C:16]([C:26]([NH2:28])=[O:27])[C:17]1=[O:18])[CH2:12]3)[CH3:1].[CH2:46]([NH:48][C:16]([CH2:15][OH:29])([CH2:17][OH:18])[CH2:26][OH:27])[C:40]([OH:44])=[O:41]

참가 물질

9

반응물 5

HCID 241BenzeneHCID 702EthanolHCID 887MethanolHCID 31374DimethylacetamideHCID 178482881HCID 178482881, 화합물

생성물 2

HCID 79784TricineHCID 178482881HCID 178482881, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

Tri-tetracycline complexes of the invention can be identified by chromatography. Minocycline was subjected to thin layer chromatography on a Kieselgel G thin layer plate in a 50:10:10:10:10:10 solvent mixture containing benzene, methanol, ethanol, ethyl acetate, dimethylformamide and dimethylacetamide. Rf of minocycline:0.16, whereas the Rf value of the complex of minocycline formed with N-tris(hydroxymethyl)methylglycine is 0.63. Chelocardin was identified in a similar way, its Rf value in the previous system is 0.21, whereas the Rf value of the complex of chelocardin formed with N-tris(hydroxymethyl)methylglycine is 0.42. The Rf value of minocycline hydrochloride on Kieselgel G thin layer plate in a 60:20:10:10 solvent system of benzene methanol, ethyl acetate and dimethylformamide is 0.1, whereas the Rf value of the complex of minocycline with tris(hydroxymethyl)aminomethane is 0.2.

출처 및 근거

ORD 기록
ord-5f60bb9a05054da6bae337f2c3edc479
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04418060

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