Tricine (HCID 79784)

이름 및 식별자

우선 이름: Tricine
IUPAC: 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
현지명: N-(트리스(하이드록시메틸)메틸)글리신
영어명: Tricine
분자식: C6H13NO5
분자량: 179.17

이름 및 동의어

Tricine5704-04-1N-Tris(hydroxymethyl)methylglycineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-W12LH4V8V32-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acidNSC-3699952-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acidDTXSID1063982CHEBI:39063n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine

이름 더 보기

N-(트리스(하이드록시메틸)메틸)글리신N-(트리스(하이드록시메틸)메틸)글리신(N-(TRIS(HYDROXYMETHYL)METHYL)GLYCINE)TRIS-HCL BUFFER1389475TROMETHAMINE HYDROCHLORIDETicineTricine buffer, free acidTRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDETRIClNEn-Tricine-D8

2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acidGlycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-RefChem:899271DTXCID6042159CHEBI:467602-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate227-193-6N-[Tris(hydroxymethyl)methyl]glycine

데이터베이스 식별자

CAS: 5704-04-1
PubChem CID: 79784
DTXSID: DTXSID1063982
ChEBI: CHEBI:39063
UNII: W12LH4V8V3
EC Number: 227-193-6
Nikkaji: J135.902I

물성

구조 계산 물성

XLogP: -5.1
극성 표면적: 110 Å²
수소 결합 공여자 수: 5
수소 결합 수용자 수: 6
회전 가능 결합 수: 6
무거운 원자 수: 12
형식 전하: 0
복잡도: 137

실험 및 물리화학적 성질

Physical DescriptionSolid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]

물리화학적 성질

녹는점: 186 · 186-188 °C (dec.)
끓는 점: 311.69 °C · 311.69°C (rough estimate)
밀도: 1.05 g/mL · 1.05 g/mL at 20 °C
증기압: 0.002 · 0.002-0.004Pa at 20-25℃
굴절률: 1.424 · 1.4240 (estimate)
저장 조건: Keep in dark place,Inert atmosphere,Room temperature
용해도: 2 O: · H2O: 4 M at 20 °C, 투명, 무색
물리적 상태: 수정 같은
색상: 투명한 무색(H2O에서 40 %(w/w)) 용액
냄새: 냄새 없는
수소이온지수(pH): 4 · 4.0-6.0 (1M in H2O)
산도 계수 (pKa): 8.1 · 8.1(at 25℃)
생물학적 소스: synthetic
수용성: 녹는
Merck: 14 · 14,9651
BRN: 1937804 · 1937804
안정성: 안정적인.
InChI: 1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)
InChIKey: SEQKRHFRPICQDD-UHFFFAOYSA-N
SMILES: OCC(CO)(CO)NCC(O)=O
LogP: -2.87 at · -2.87 at 25℃
EPA: 2 · Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]- (5704-04-1)
Absorption: 0.05 at · ≤0.05 at 280 in H2O at 1M≤0.1 at 260 in H2O at 1M

화학적 성질

White/clear crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 3건

This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 121 of 124 companies (only 2.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 121 of 124 reports by companies.；There are 3 notifications provided by 3 of 124 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 3건

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]

Hazard Classes and CategoriesNot Classified

규제 정보

Regulatory Information · 3건

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 3
tsca: TSCA listed
HS 번호: 29052900
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36-36/37/39
F 고인화성물질: 3
스토리지 클래스: 13 - Non Combustible Solids

화학 및 산업

용도 및 제조

UsesUsed as a biological buffer; [Merck Index]

General Manufacturing InformationGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-: ACTIVE

응용 분야 · 2건

용도Good's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets. It is a zwitterionic amino acid commonly useful in the pH range of 7.4-8.8 and the pKa is 8.05 at 25°C. This buffer is also used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).

일반 설명Tricine and its salts are used as biological buffers to control the pH of body fluids in vitro and in vivo. It acts as a precursor for polymers, oxazolones (with carboxylic acids), and oxazolidines (with aldehydes). Trizma can serve as an alkalizing agent in treating acidosis of the blood.