N-(트리스(하이드록시메틸)메틸)글리신
Tricine
기본 정보
- CAS
5704-04-1- 표준 SMILES
O=C(O)CNC(CO)(CO)CO- InChIKey
SEQKRHFRPICQDD-UHFFFAOYSA-N- 분자식
- C6H13NO5
- 평균 분자량
- 179.17 g/mol
- 단동위원소 질량
- 179.07937252
개요
N-tris(hydroxymethyl)methylglycine is a Good's buffer substance, pKa = 8.15 at 20 C. It is functionally related to a glycine and a member of tris. It is a tautomer of a N-tris(hydroxymethyl)methylammonioacetate.
이름 및 식별자
- 우선 이름
- Tricine
- IUPAC
- 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
- 현지명
- N-(트리스(하이드록시메틸)메틸)글리신
- 영어명
- Tricine
- 분자식
- C6H13NO5
- 분자량
- 179.17
이름 및 동의어
Tricine5704-04-1N-Tris(hydroxymethyl)methylglycineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-2-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acidW12LH4V8V3NSC-3699952-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acidDTXSID1063982CHEBI:39063n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine
이름 더 보기
N-(트리스(하이드록시메틸)메틸)글리신N-(트리스(하이드록시메틸)메틸)글리신(N-(TRIS(HYDROXYMETHYL)METHYL)GLYCINE)TRIS-HCL BUFFER1389475TROMETHAMINE HYDROCHLORIDETicineTricine buffer, free acidTRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDETRIClNEn-Tricine-D8
2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acidGlycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-RefChem:899271DTXCID6042159CHEBI:467602-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate227-193-6N-[Tris(hydroxymethyl)methyl]glycine
데이터베이스 식별자
- CAS
5704-04-1- PubChem CID
- 79784
- DTXSID
DTXSID1063982- ChEBI
CHEBI:39063- UNII
- W12LH4V8V3
- EC Number
- 227-193-6
- Nikkaji
- J135.902I
물성
구조 계산 물성
- XLogP
- -5.1
- 극성 표면적
- 110 Ų
- 수소 결합 공여자 수
- 5
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 12
- 형식 전하
- 0
- 복잡도
- 137
실험 및 물리화학적 성질
Chemical ClassesOther Uses -> Biological Buffers
Physical DescriptionSolid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]
물리화학적 성질
- 녹는점
- 186 · 186-188 °C (dec.)
- 끓는 점
- 311.69 °C · 311.69°C (rough estimate)
- 밀도
- 1.05 g/mL · 1.05 g/mL at 20 °C
- 증기압
- 0.002 · 0.002-0.004Pa at 20-25℃
- 굴절률
- 1.424 · 1.4240 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- 2 O: · H2O: 4 M at 20 °C, 투명, 무색
- 물리적 상태
- 수정 같은
- 색상
- 투명한 무색(H2O에서 40 %(w/w)) 용액
- 냄새
- 냄새 없는
- 수소이온지수(pH)
- 4 · 4.0-6.0 (1M in H2O)
- 산도 계수 (pKa)
- 8.1 · 8.1(at 25℃)
- 생물학적 소스
- synthetic
- 수용성
- 녹는
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.
Not Classified
Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.
유해성 정보
Regulatory Information
Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-
REACH registered substance: N-(tri(hydroxymethyl)methyl)glycine (EC: 227-193-6)
Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesNot Classified
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- HS 번호
- 29052900
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36-36/37/39
- F 고인화성물질
- 3
- 스토리지 클래스
- 13 - Non Combustible Solids
화학 및 산업
용도 및 제조
UsesUsed as a biological buffer; [Merck Index]
General Manufacturing InformationGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-: ACTIVE
응용 분야
용도Good's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets. It is a zwitterionic amino acid commonly useful in the pH range of 7.4-8.8 and the pKa is 8.05 at 25°C. This buffer is also used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).
일반 설명Tricine and its salts are used as biological buffers to control the pH of body fluids in vitro and in vivo. It acts as a precursor for polymers, oxazolones (with carboxylic acids), and oxazolidines (with aldehydes). Trizma can serve as an alkalizing agent in treating acidosis of the blood.
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