Sodium Bicarbonate → Ethyl 2,4-difluoro-3-amino-2-butenoate

HRID 1649555노트

반응식

HRID 1649555 반응식
[F:1][CH:2]([C:8](=O)[CH2:9][F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C([O-])(=O)C.[NH4+:16].C(=O)(O)[O-].[Na+]>CO>[F:1][C:2](=[C:8]([NH2:16])[CH2:9][F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 517165Ammonium AcetateHCID 15207128Ethyl 2,4-difluoro-3-oxobutanoate

생성물 1

HCID 86020216Ethyl 2,4-difluoro-3-amino-2-butenoate수율 45.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of ethyl 2,4-difluoro-3-oxobutanoate (24.6 g, 0.148 mol), ammonium acetate (200 g, 2.6 mol) and anhydrous methanol (400 mL) is stirred at room temperature for 3 days. The solution is poured into a saturated aqueous solution of sodium bicarbonate (1L) and extracted four times with ether. The combined organic phases are washed with brine and dried over magnesium sulfate. The solvent is evaporated to yield ethyl 2,4-difluoro-3-amino-2-butenoate (11.1 g, 45%)

후처리

  1. extractionextracted four times with ether
  2. washThe combined organic phases are washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-1431f428058743c0a055444f4d89764d
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04418077

반응 노트

불러오는 중…