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Sodium Hydroxide → Sodium 7beta-(p-methoxybenzyloxycarbonylamino)-3-hydroxymethyl-3-cephem-4-carboxylate

HRID 1649753
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HRID 1649753 반응식
[NH2:1][C@@H:2]1[C:14](=[O:15])[N:4]2[C:5]([C:11]([OH:13])=[O:12])=[C:6]([CH2:9][OH:10])[CH2:7][S:8][C@H:3]12.[OH-].[Na+:17].[CH3:18][O:19][C:20]1[CH:38]=[CH:37][C:23]([CH2:24][O:25][C:26](SC2C=C(C)C=C(C)N=2)=[O:27])=[CH:22][CH:21]=1.O1CCOCC1>O.C(OCC)(=O)C>[CH3:18][O:19][C:20]1[CH:38]=[CH:37][C:23]([CH2:24][O:25][C:26]([NH:1][C@@H:2]2[C:14](=[O:15])[N:4]3[C:5]([C:11]([O-:13])=[O:12])=[C:6]([CH2:9][OH:10])[CH2:7][S:8][C@H:3]23)=[O:27])=[CH:22][CH:21]=1.[Na+:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 11031679(6R-trans)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acidHCID 13505496S-p-methoxybenzyloxycarbonyl-4,6-dimethyl-2-mercaptopyridine

생성물 1

HCID 67868099Sodium 7beta-(p-methoxybenzyloxycarbonylamino)-3-hydroxymethyl-3-cephem-4-carboxylate

시약·촉매·용매

2
HCID 962Water용매2회HCID 8857Ethyl Acetate용매

실험 절차

In 50 ml of water is suspended 2.30 g of 7β-amino-3-hydroxymethyl-3-cephem-4-carboxylic acid and the suspension is adjusted to pH 8.5 with 1N-aqueous sodium hydroxide solution, whereupon a clear solution is obtained. To this solution are added 4.56 g of S-p-methoxybenzyloxycarbonyl-4,6-dimethyl-2-mercaptopyridine and 50 ml of dioxane and the mixture is stirred at room temperature for 7 hours. The reaction mixture is diluted with water and ethyl acetate and the water layer is separated and concentrated under reduced pressure. The residue is subjected to XAD-II (500 ml) column chromatography and after the column is washed with water, elution is carried out with 10% (v/v) ethanol. The eluate is concentrated under reduced pressure and freeze-dried to give 1.63 g of sodium 7β-(p-methoxybenzyloxycarbonylamino)-3-hydroxymethyl-3-cephem-4-carboxylate as colorless powders.

후처리

  1. customis obtained
  2. customthe water layer is separated
  3. concentrationconcentrated under reduced pressure
  4. washafter the column is washed with water, elution
  5. concentrationThe eluate is concentrated under reduced pressure
  6. customfreeze-dried

출처 및 근거

ORD 기록
ord-769264b41c0d43e381685c7878292218
출처 데이터셋
uspto-grants-1990_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04921851

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