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Potassium Iodide → HCID 14280680, 화합물

HRID 1649774
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HRID 1649774 반응식
[Cl:1][CH2:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1.[F:14][C:15]1[CH:27]=[CH:26][C:18]([CH2:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[CH:17][CH:16]=1.[I-].[K+].C(=O)([O-])O.[Na+]>C(O)CCC>[ClH:1].[F:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH:20]2[CH2:21][CH2:22][N:23]([CH2:2][CH2:3][C:4]3[CH:13]=[CH:12][C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[CH:5]=3)[CH2:24][CH2:25]2)=[CH:26][CH:27]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 516892Sodium BicarbonateHCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 12698954HCID 12698954, 화합물

생성물 1

HCID 14280680HCID 14280680, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

1.05 g of 1-chloro-2-(2-naphthyl)ethane, 1.09 g of 4-(p-fluorobenzyl)piperidine, 0.2 g of potassium iodide and 1.4 g of sodium hydrogencarbonate were refluxed in n-butanol solvent for 5 h. Then, the solvent was filtered out and 100 ml of chloroform was added to the residue. The mixture was washed with water and dried over magnesium sulfate. The oily product thus obtained was purified according to silica gel column chromatography and converted into its hydrochloride by an ordinary method.

후처리

  1. filtrationThen, the solvent was filtered out and 100 ml of chloroform
  2. additionwas added to the residue
  3. washThe mixture was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe oily product thus obtained
  6. customwas purified

출처 및 근거

ORD 기록
ord-2125b56587654f56aba5c0186169006c
출처 데이터셋
uspto-grants-1990_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04921863

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