Sodium Hydroxide → 1-(2,4-Dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol

HRID 1649781

반응식

HRID 1649781 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:16])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[OH-:17].[Na+].[Cl:19][C:20]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:21]=1[O:22][CH2:23][CH2:24]Br>C1(C)C=CC=CC=1.[Cl-].C([N+](CCCCCCCCCCCC)(C)C)C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([O:17][CH2:24][CH2:23][O:22][C:21]1[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:20]=1[Cl:19])([OH:16])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 1388811-(2-Bromoethoxy)-2,4-dichlorobenzeneHCID 66285758905-18-3

생성물 1

HCID 540910161-(2,4-Dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol수율 35%

시약·촉매·용매 2

HCID 8753Benzododecinium Chloride촉매HCID 1140Toluene용매

실험 절차

12.95 g (0.05 mole) of 1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-1-ethanol are dissolved in 100 ml of toluene, and 100 ml of 40% strength sodium hydroxide solution and 1 ml of benzyl-dodecyl-dimethylammonium chloride are added. 13.5 g (0.05 mole) of 2,4-dichlorophenoxyethyl bromide are then added dropwise and the mixture is subsequently stirred at room temperature for 48 hours. The organic phase is separated off, washed with three 100 ml portions of saturated sodium chloride solution, dried over sodium sulphate and concentrated. The residue is taken up in 100 ml of diethyl ether, and crystallizes after the mixture has stood for a short time. 7.8 g (35% of theory) of 1-(2,4-dichlorophenyl)-1-(2,4-dichlorophenoxyethoxy)-2-(1,2,4-triazol-1-yl)-1-ethanol of melting point 88°-90° C. are obtained.

후처리

  1. customThe organic phase is separated off
  2. washwashed with three 100 ml portions of saturated sodium chloride solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated
  5. customcrystallizes after the mixture

출처 및 근거

ORD 기록
ord-4bd5082c1bf1429e8c2e90a042b4904b
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04921870

연결된 노트

불러오는 중…