Hydrogen Bromide → 2-(4-Chlorobenzyl)-4-hydroxy-7-methylbenzimidazole hydrobromide

반응식

[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][C:7]2[NH:8][C:9]3[C:15]([O:16]C)=[CH:14][CH:13]=[C:12]([CH3:18])[C:10]=3[N:11]=2)=[CH:4][CH:3]=1.[BrH:21]>>[BrH:21].[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][C:7]2[NH:8][C:9]3[C:15]([OH:16])=[CH:14][CH:13]=[C:12]([CH3:18])[C:10]=3[N:11]=2)=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 139713472-(4-Chlorobenzyl)-4-methoxy-7-methylbenzimidazole

생성물 1

HCID 230523862-(4-Chlorobenzyl)-4-hydroxy-7-methylbenzimidazole hydrobromide

실험 절차

A suspension of 2-(4-chlorobenzyl)-4-methoxy-7-methylbenzimidazole (4.0 g) in 48% aqueous hydrobromic acid (400 ml) under nitrogen was heated at 130° for 5 h, then evaporated to dryness in vacuo. The residue was recrystallized from ethanol-ether to afford the title compound (3.95 g), m.p. 275°-277° C.

후처리

temperaturewas heated at 130° for 5 h
customevaporated to dryness in vacuo
customThe residue was recrystallized from ethanol-ether

출처 및 근거

ORD 기록: ord-5bb703b84ccb489d9ad50685be3b4537
출처 데이터셋: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04925853

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