alphahydroxy-N-[1-methyl-4-(3-pyridinyl)butyl]benzeneacetamide → (S)-2-Amino-5-(3-pyridyl)pentane
반응식
OC(C1C=CC=CC=1)C([NH:5][CH:6]([CH3:16])[CH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=O>Cl>[CH3:16][C@H:6]([NH2:5])[CH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1참가 물질
3
실험 절차
A solution of 160 g of crude [S-(R*,R*)]-alpha-hydroxy-N-[1-methyl-4-(3-pyridinyl)butyl]benzeneacetamide in 800 mL of 6N HCl was treated with 85 mL conc. HCl and then was heated at reflux overnight as described in Example 16. The crude amine (~85 g), isolated in the normal manner, was distilled to furnish 76.4 g of (S)-alpha-methyl-3-pyridinebutanamine, (60%ee; bp 89°-91°/0.15 mm).
후처리
- temperaturewas heated
- temperatureat reflux overnight
- customThe crude amine (~85 g), isolated in the normal manner
- distillationwas distilled
출처 및 근거
- ORD 기록
- ord-5fec6c6993ef44a0a05d742792c8391e
- 출처 데이터셋
- uspto-grants-1990_05
- 특허 번호
- US04927826
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