Sodium Hydroxide → (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid

HRID 1651271노트

반응식

HRID 1651271 반응식
C[O:2][C:3](=[O:22])/[CH:4]=[CH:5]/[C:6]1[O:7][C:8]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:9]=2[C:10]=1[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[OH-].[Na+]>CO>[CH3:21][O:20][C:18]1[CH:17]=[CH:16][C:9]2[C:10]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:22])=[O:2])[O:7][C:8]=2[CH:19]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 14742791(E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid methyl ester

생성물 1

HCID 14742803(E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid수율 88.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

As in Example 112, (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid methyl ester (4.25 g) in methanol (25 mL) was treated with 2N sodium hydroxide solution (15 mL) at reflux for 1.25 hours. The crude reaction product was crystallized from ethyl acetate to provide 3.6 g of (E)-3-(6-methoxy-3-pentylbenzofuran-2-yl)-2-propenoic acid, mp 146°-147° C. Anal. Calcd for C17H20O4 : C, 70.81; H, 6.99 Found: C, 70.51; H, 6.89

후처리

  1. temperatureat reflux for 1.25 hours
  2. customThe crude reaction product
  3. customwas crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-3550023565dc417f8ed008453e00080e
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04927838

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