Chloroacetyl chloride → 5-t-butyl-2-methoxy-3-(chloroacetamido) phenyl N-t-butylsulfonamide

HRID 1651477노트

반응식

HRID 1651477 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]([C:10]1[CH:11]=[C:12]([NH2:26])[C:13]([O:24][CH3:25])=[C:14]([S:16]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])=[O:17])[CH:15]=1)([CH3:9])([CH3:8])[CH3:7].C(N(C(C)C)CC)(C)C>ClCCl>[C:6]([C:10]1[CH:11]=[C:12]([NH:26][C:3](=[O:4])[CH2:2][Cl:1])[C:13]([O:24][CH3:25])=[C:14]([S:16]([NH:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:17])=[O:18])[CH:15]=1)([CH3:9])([CH3:7])[CH3:8]

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 150295865-t-butyl-2-methoxy-3-aminophenyl N-t-butyl sulfonamide

생성물 1

HCID 150295875-t-butyl-2-methoxy-3-(chloroacetamido) phenyl N-t-butylsulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of chloroacetyl chloride (4.4 ml) in dichloromethane (40 ml) was added dropwise to a cooled and stirred solution of 5-t-butyl-2-methoxy-3-aminophenyl N-t-butyl-sulfonamide (15.6 g) and diisopropylethylamine (9.5 ml) in dichloromethane (100 ml). The solution was left standing at ambient temperature for 2 hours and then washed with a 2% solution of citric acid. The organic phase was dried and evaporated. Recrytallization from aqueous ethanol gave the title compound (16.4 g).

후처리

  1. temperaturea cooled
  2. waitThe solution was left
  3. washwashed with a 2% solution of citric acid
  4. customThe organic phase was dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-979e8240d54b4415a395bd82d5be5d51
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929269

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