Ethyl 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]-propionate → HCID 15055866, 화합물

HRID 1651558

반응식

HRID 1651558 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]([O:20]CC)=[O:19])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1>[OH-].[Na+].C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 15055865Ethyl 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]-propionate

생성물 1

HCID 15055866HCID 15055866, 화합물수율 92.5%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

1.00 g (2.48 mmol) of ethyl 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]propionate obtained in Example 24 was dissolved in a mixed solution of 1 ml of 50 wt % of aqueous sodium hydroxide and 8 ml of ethanol, and the solution was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, neutralized with dil. hydrochloric acid and then extracted with chloroform. The chloroform extract was dried over anhydrous sodium sulfate and then concentrated to give 0.86 g (92%) of 3-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]propionic acid.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionextracted with chloroform
  3. extractionThe chloroform extract
  4. dry with materialwas dried over anhydrous sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-87790da58855434a9fdd1f40c701393b
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929618

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