Hydrochloric Acid → HCID 19915159, 화합물

HRID 1651588노트

반응식

HRID 1651588 반응식
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][CH:11]([N:14]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:10]2)=[C:4]([F:25])[CH:3]=1.[ClH:26]>C(O)C>[ClH:26].[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10]2)=[C:4]([F:25])[CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 14770834HCID 14770834, 화합물

생성물 1

HCID 19915159HCID 19915159, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 20.3 g (50 mmol) of 2-[3-(4-bromo-2,5-difluorophenyl)cyclopentyl]-1H-isoindole-1,3-(2H)-dione in 100 ml of concentrated hydrochloric acid and 100 ml of ethanol was heated at reflux for 4 hours. The ethanol was allowed to evaporate and the aqueous acid mixture was heated at reflux for 4 additional hours. The solution was filtered through a fiber glass pad to remove some insoluble material and the filtrate was evaporated in vacuo. The residue was triturated with ethanol which was also removed in vacuo to give 13.1 g of the title compound.

후처리

  1. temperatureat reflux for 4 hours
  2. customto evaporate
  3. temperaturethe aqueous acid mixture was heated
  4. temperatureat reflux for 4 additional hours
  5. filtrationThe solution was filtered through a fiber glass pad
  6. customto remove some insoluble material
  7. customthe filtrate was evaporated in vacuo
  8. customThe residue was triturated with ethanol which
  9. customwas also removed in vacuo

출처 및 근거

ORD 기록
ord-85d66fb64edc430796a6ef044442031b
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929613

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