Aluminum → Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)-

HRID 1651748

반응식

HRID 1651748 반응식
[Al].[C:2]([NH:10][C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([N+:18]([O-])=O)=[CH:13][C:12]=1[OH:21])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>[Co].[Cr].[Ni]>[NH2:18][C:14]1[C:15]([Cl:17])=[CH:16][C:11]([NH:10][C:2](=[O:9])[C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)=[C:12]([OH:21])[CH:13]=1

참가 물질

6

반응물 2

HCID 5359268AluminumHCID 5483228Benzamide, N-(5-chloro-2-hydroxy-4-nitrophenyl)-

생성물 1

HCID 78779Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)-

시약·촉매·용매 3

HCID 935Nickel촉매HCID 23976Chromium촉매HCID 104730Cobalt촉매2회

실험 절차

Using the procedure described above and 5.0 g of a chromium-containing Raney cobalt catalyst containing about 20-30 weight percent aluminum, 1.5 to 2.5 weight percent nickel and the remainder cobalt, 2-benzamido 4-chloro 5-nitrophenol is hydrogenated for a total of 4 hours to obtain the corresponding amine, 5-amino 2-benzamido 4-chlorophenol. Analysis of a sample of the reaction mixture taken and analyzed in accordance with the procedure used in the preceding example, show that the purity of the product is 98.4 percent and the presence of 0.1 percent of dechlorinated by product. The azo, azoxy and hydroxylamine intermediate products are soluble in the final filtrate and thus are easily removed from the product. No starting material is detected.

후처리

  1. customis hydrogenated for a total of 4 hours

출처 및 근거

ORD 기록
ord-c7ba2b9b250d4e90b4c69e31f0088994
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929737

연결된 노트

불러오는 중…