Hydrazine hydrate (1:1) → 6-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

HRID 1651869노트

반응식

HRID 1651869 반응식
[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20](=O)[CH2:21][CH2:22][C:23]([OH:25])=O)[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:28][NH2:29]>C(O)(=O)C>[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20]4[CH2:21][CH2:22][C:23](=[O:25])[NH:28][N:29]=4)[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 14071508HCID 14071508, 화합물

생성물 1

HCID 140715226-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3.0 g (8 mmol) of 4-(2-benzenesulphonamido-indan-5-yl)-4-oxobutyric acid and 0.53 g (10.4 mmol) of 99% hydrazine hydrate in 12 ml of glacial acetic acid are boiled for 3 hours. The mixture is evaporated in vacuo, water is added to the residue, which is neutralised with sodium carbonate solution, and the reaction product is filtered off with suction and recrystallised from n-propanol.

후처리

  1. customThe mixture is evaporated in vacuo, water
  2. additionis added to the residue, which
  3. filtrationthe reaction product is filtered off with suction
  4. customrecrystallised from n-propanol

출처 및 근거

ORD 기록
ord-30d0a460096746d8852e149c1a17b75a
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929754

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