Trifluoroiodoethylene → 4-[4-(4-Propylcyclohexyl)cyclohexyl]-1-(1,2,2-trifluorovinyl)benzene

HRID 1653611

반응식

HRID 1653611 반응식
[F:1][C:2]([F:6])=[C:3]([F:5])I.I[C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][CH:17]([CH:20]3[CH2:25][CH2:24][CH:23]([CH2:26][CH2:27][CH3:28])[CH2:22][CH2:21]3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1>[Zn].C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1COCC1>[CH2:26]([CH:23]1[CH2:22][CH2:21][CH:20]([CH:17]2[CH2:18][CH2:19][CH:14]([C:11]3[CH:12]=[CH:13][C:8]([C:3]([F:5])=[C:2]([F:6])[F:1])=[CH:9][CH:10]=3)[CH2:15][CH2:16]2)[CH2:25][CH2:24]1)[CH2:27][CH3:28]

참가 물질

6

반응물 2

HCID 67755TrifluoroiodoethyleneHCID 13931028(trans,trans)-4-(4-Iodophenyl)-4'-propyl-1,1'-bi(cyclohexane)

생성물 1

HCID 200802044-[4-(4-Propylcyclohexyl)cyclohexyl]-1-(1,2,2-trifluorovinyl)benzene

시약·촉매·용매 3

HCID 23994Zinc촉매HCID 178418397HCID 178418397, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 5.0 g (77 mmol) of zinc powder, 50 ml of THF and 13.5 g (65 mmol) of trifluoroiodoethylene is stirred overnight, initially with ice cooling, later at room temperature. 20.5 g (50 mmol) of 1-iodo-4-[4-(4-propylcyclohexyl)cyclohexyl]benzene and 1.1 g-of tetrakis(triphenylphosphine)palladium are then added.

출처 및 근거

ORD 기록
ord-9e3c7aec233d464aa7cfacce147fef7c
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05403512

연결된 노트

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