Potassium thiocyanate → (3-Chloro-2-methylphenyl)thiosemicarbazide

HRID 1654068노트

반응식

HRID 1654068 반응식
Cl.[Cl:2][C:3]1[C:4]([CH3:11])=[C:5]([NH:9][NH2:10])[CH:6]=[CH:7][CH:8]=1.[S-:12][C:13]#[N:14].[K+]>C(O)C>[Cl:2][C:3]1[C:4]([CH3:11])=[C:5]([NH:9][NH:10][C:13]([NH2:14])=[S:12])[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 516872Potassium thiocyanateHCID 12732296(3-Chloro-2-methylphenyl)hydrazine hydrochloride

생성물 1

HCID 20079518(3-Chloro-2-methylphenyl)thiosemicarbazide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

19.3 g (0.1 mole) of 3-chloro-2-methylphenylhydrazinehydrochloride were dissolved in 200 ml of absolute ethanol. 11.64 g (0.12 mole) of potassium thiocyanate were added to the solution, and the mixture was heated during reflux for 16 hours. The mixture was then cooled, whereby the product was partially precipitated, and the mixture was subsequently evaporated to dryness by means of a rotating evaporator. The product was recrystallized from 200 ml water and 250 ml methanol, separated by filtration and washed thoroughly with water.

후처리

  1. temperaturethe mixture was heated
  2. temperatureduring reflux for 16 hours
  3. temperatureThe mixture was then cooled
  4. customwhereby the product was partially precipitated
  5. customthe mixture was subsequently evaporated to dryness by means of a rotating evaporator
  6. customThe product was recrystallized from 200 ml water and 250 ml methanol
  7. customseparated by filtration
  8. washwashed thoroughly with water

출처 및 근거

ORD 기록
ord-b1c751435ff54ea888fe464c8808333d
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05405857

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