Thionyl Chloride → 4-(Chloromethyl)-2-cyclopropylthiazole hydrochloride

HRID 1654212노트

반응식

HRID 1654212 반응식
[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([CH2:9]O)[N:8]=2)[CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[ClH:13].[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([CH2:9][Cl:13])[N:8]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 20079576(2-Cyclopropylthiazol-4-yl)methanol

생성물 1

HCID 187591664-(Chloromethyl)-2-cyclopropylthiazole hydrochloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

In chloroform (10 ml) was dissolved 2-cyclopropyl-4-hydroxymethylthiazole (0.9 g), to which was added dropwise, under ice-cooling, thionyl chloride (0.68 ml), followed by stirring for 30 minutes at room temperature. Excess thionyl chloride was distilled off under reduced pressure. To the residue was added diethyl ether to yield 2-cyclopropyl-4-chloromethyl thiazole hydrochloride (1.1 g) as pale brown powder. m.p. 108°-110° C.

후처리

  1. additionto which was added dropwise, under ice-
  2. temperaturecooling
  3. distillationExcess thionyl chloride was distilled off under reduced pressure
  4. additionTo the residue was added diethyl ether

출처 및 근거

ORD 기록
ord-21dbd786b3184c6bb3ae790f12765813
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05405861

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