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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → 7-(1-Amino-6-azaspiro[2.5]oct-6-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, hydrochloride salt

HRID 1654515
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인쇄 미리보기

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HRID 1654515 반응식
C(OC([NH:8][CH:9]1[C:11]2([CH2:16][CH2:15][N:14]([C:17]3[N:26]=[C:25]4[C:20]([C:21](=[O:40])[C:22]([C:35]([O:37]CC)=[O:36])=[CH:23][N:24]4[C:27]4[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=4[F:34])=[CH:19][C:18]=3[F:41])[CH2:13][CH2:12]2)[CH2:10]1)=O)(C)(C)C.[ClH:42]>C(OCC)(=O)C>[ClH:42].[NH2:8][CH:9]1[C:11]2([CH2:12][CH2:13][N:14]([C:17]3[N:26]=[C:25]4[C:20]([C:21](=[O:40])[C:22]([C:35]([OH:37])=[O:36])=[CH:23][N:24]4[C:27]4[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=4[F:34])=[CH:19][C:18]=3[F:41])[CH2:15][CH2:16]2)[CH2:10]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 152821727-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carbOxylic acid, ethyl ester

생성물 1

HCID 1317189627-(1-Amino-6-azaspiro[2.5]oct-6-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, hydrochloride salt수율 38%

시약·촉매·용매 1

HCID 8857Ethyl Acetate
용매

실험 절차

A solution of the compound of step A (441 mg, 0.77 mmol) in ethyl acetate (9 ml) and 3N hydrogen chloride (9 ml) was heated to reflux overnight. solvents were removed in vacuo and the residue was recrystallized from methanolacetonitrile to give the title product as a yellow solid, mp 217° C. (decomap.), (133 mg, 0.29 mmol, 38% yield).

후처리

  1. temperatureto reflux overnight
  2. customsolvents were removed in vacuo
  3. customthe residue was recrystallized from methanolacetonitrile

출처 및 근거

ORD 기록
ord-7ac4bc56156e46499f4e2d2c29192668
출처 데이터셋
uspto-grants-1995_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05407943

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