Dichloromethane → 1-Phenyl-3-(2-furanyl)-2-propyne-1-one

HRID 1654777

반응식

HRID 1654777 반응식
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.C(Cl)Cl.[O:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[C:30]#[C:31][CH:32]([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[OH:33]>C(OCC)C>[C:34]1([C:32](=[O:33])[C:31]#[C:30][C:26]2[O:25][CH:29]=[CH:28][CH:27]=2)[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 2724130Cornforth reagentHCID 20076917alpha-[(2-Furanyl)ethynyl]-benzenemethanol

생성물 1

HCID 144017341-Phenyl-3-(2-furanyl)-2-propyne-1-one

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Place pyridinium dichromate (0.75 g, 2 mmol) and methylene chloride (15 mL) under argon atmosphere and cool to 0° C. Add α-[(2-furanyl)ethynyl]-benzenemethanol (297 mg, 1.5 mmol). Stir overnight while slowly warming to room temperature. Dilute with ethyl ether and filter the chromium salts. Purify by silica gel chromatography to give the title compound.

후처리

  1. filtrationfilter the chromium salts
  2. customPurify by silica gel chromatography

출처 및 근거

ORD 기록
ord-a42f66b7f987487399e9614f7813cf37
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409942

연결된 노트

불러오는 중…