2-Amino-3-Hydroxypyridine → 3-[(4-Methoxybenzyl)oxy]pyridin-2-amine

HRID 1654826노트

반응식

HRID 1654826 반응식
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Br)=[CH:5][CH:4]=1.[NH2:11][C:12]1[C:17]([OH:18])=[CH:16][CH:15]=[CH:14][N:13]=1>[OH-].[Na+].ClCCl.CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-].O>[NH2:11][C:12]1[C:17]([O:18][CH2:7][C:6]2[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:16][CH:15]=[CH:14][N:13]=1

참가 물질

7

반응물 2

HCID 281142-Amino-3-HydroxypyridineHCID 1650214-Methoxybenzyl bromide

생성물 1

HCID 27283893-[(4-Methoxybenzyl)oxy]pyridin-2-amine수율 76.7%

시약·촉매·용매 4

HCID 21218Trioctylmethylammonium chloride촉매HCID 962Water용매HCID 6344Dichloromethane용매2회HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 4-methoxybenzyl bromide (25 g, 0.159 mol) and 2-amino-3-hydroxypyridine (15.9 g, 0.145 mol) in 40% aqueous sodium hydroxide solution (150 ml) and dichloromethane (150 ml) was treated with Adogen 464 (5 ml) and stirred vigorously at room temperature for 16 hours. The mixture was diluted with further water and dichloromethane, the product extracted into dichloromethane, and the combined organic layers washed with water, dried and evaporated. The resulting solid was washed with ether to yield the product (25.6 g, 70%)

후처리

  1. extractionthe product extracted into dichloromethane
  2. washthe combined organic layers washed with water
  3. customdried
  4. customevaporated
  5. washThe resulting solid was washed with ether

출처 및 근거

ORD 기록
ord-c45126958ef04d6a85f2ce607e71d9cf
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

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