Toluene → N-[3-(4-Methoxybenzyloxy)pyrid-2-yl]-N'-phenylthiourea

HRID 1654880노트

반응식

HRID 1654880 반응식
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:18]1([N:24]=[C:25]=[S:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C1(C)C=CC=CC=1>C(OCC)C>[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][O:8][C:7]2[C:2]([NH:1][C:25]([NH:24][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[S:26])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 7673Phenyl IsothiocyanateHCID 27283893-[(4-Methoxybenzyl)oxy]pyridin-2-amine

생성물 1

HCID 20076982N-[3-(4-Methoxybenzyloxy)pyrid-2-yl]-N'-phenylthiourea

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-amino-3-(4-methoxybenzyloxy)pyridine (1.91 g, 0.0083 mol), phenyl isothiocyanate (1.4 g, 0.01 mol) and toluene (10 ml) was refluxed for 3.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 2.18 g (72%), m.p. 123°-125 ° C.

후처리

  1. temperaturewas refluxed for 3.5 hours
  2. temperaturecooled
  3. customcrystallisation of the product

출처 및 근거

ORD 기록
ord-a2681fa8ea7a4ddeb3f2ce3dfa836485
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

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