Dichloromethane → HCID 12758273, 화합물

HRID 1654884노트

반응식

HRID 1654884 반응식
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:10][Cl:11].[OH-].[Na+].Cl[C:15]1[CH:22]=C[CH:20]=[CH:19][C:16]=1[CH2:17]Br>CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-].O>[NH2:1][C:2]1[C:7]([O:8][CH2:17][C:16]2[CH:19]=[CH:20][C:10]([Cl:11])=[CH:22][CH:15]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 11905alpha-Bromo-o-chlorotolueneHCID 14798Sodium HydroxideHCID 281142-Amino-3-Hydroxypyridine

생성물 1

HCID 12758273HCID 12758273, 화합물

시약·촉매·용매 2

HCID 21218Trioctylmethylammonium chloride촉매HCID 962Water용매

실험 절차

A mixture of 2-amino-3-hydroxy pyridine (3.45 g, 0.313 mol), dichloromethane (20 ml) and 40% aqueous sodium hydroxide solution (20 ml) was stirred for five minutes, then 2chlorobenzyl bromide (6.09 g, 0.0315 mol) and Adogen 464 (3 ml) were added and stirring continued for 16 hours. The mixture was diluted with water and extracted with dichloromethane. Drying and evaporation of the organic extracts, and trituration with ether gave the desired product. Yield 3.5 g (48%), m.p. 121°-123 ° C.

후처리

  1. stirringstirring
  2. waitcontinued for 16 hours
  3. extractionextracted with dichloromethane
  4. customDrying
  5. customevaporation of the organic extracts, and trituration with ether

출처 및 근거

ORD 기록
ord-23eb50db7f2b45cd92f413edf74688d1
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

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