Toluene → HCID 20076930, 화합물

HRID 1654885노트

반응식

HRID 1654885 반응식
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:17]1([N:23]=[C:24]=[S:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C1(C)C=CC=CC=1>C(OCC)C>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][O:8][C:7]2[C:2]([NH:1][C:24]([NH:23][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[S:25])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 7673Phenyl IsothiocyanateHCID 12758273HCID 12758273, 화합물

생성물 1

HCID 20076930HCID 20076930, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-amino-3-(4-chlorobenzyloxy)pyridine (3.37 g, 0,014 mol), phenyl isothiocyanate (2.33 g, 0,017 mol) and toluene (10 ml) was refluxed for 3.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 4.36 g (82%), m.p. 162°-164 ° C.

후처리

  1. temperaturewas refluxed for 3.5 hours
  2. temperaturecooled
  3. customcrystallisation of the product

출처 및 근거

ORD 기록
ord-2d6f9c75c39440e4ac3bd8b4e271dc0c
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

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