Toluene → 3-(2,4,6-Trifluorobenzyloxy)pyrid-2-yl-N'-(4-chlorophenyl)thiourea

HRID 1654911

반응식

HRID 1654911 반응식
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[C:15]([F:16])=[CH:14][C:13]([F:17])=[CH:12][C:11]=2[F:18])=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[S:28])=[CH:22][CH:21]=1.C1(C)C=CC=CC=1>C(OCC)C>[F:16][C:15]1[CH:14]=[C:13]([F:17])[CH:12]=[C:11]([F:18])[C:10]=1[CH2:9][O:8][C:7]1[C:2]([NH:1][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=2)=[S:28])=[N:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 164804-Chlorophenyl isothiocyanateHCID 100151612-Amino-3-(2,4,6-trifluorobenzyloxy)pyridine

생성물 1

HCID 200770093-(2,4,6-Trifluorobenzyloxy)pyrid-2-yl-N'-(4-chlorophenyl)thiourea

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-amino-3-(2,4,6-trifluorobenzyloxy)pyridine (2.29 g, 0.009 mol), 4chlorophenyl isothiocyanate (1.81 g, 0.01 mol) and toluene (10 ml) was refluxed for 3.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 3.03 g (79.5%), m.p.181°-183 ° C.

후처리

  1. temperaturewas refluxed for 3.5 hours
  2. temperaturecooled
  3. customcrystallisation of the product

출처 및 근거

ORD 기록
ord-2c38946663564af9b9e2c72d913ca0cc
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

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